Anti-Cancer Benefit Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Breast Cancer

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Anti-Cancer Benefit Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Breast Cancer




Xao tam phan (Paramignya trimera (Oliv.) Guillaum) can be a Vietnamese traditionally medicinal plant utilized in the treatment of numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. This study aimed to research the consequences of five various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The results indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the greatest antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (except for total flavonoids) and antioxidant capacity, when compared to conventional and ultrasound-assisted extractions. These data show that using methanol and microwave-assisted extraction are suggested for extraction of biologically active phytochemicals from P. trimera root for application from the nutraceutical and/or pharmaceutical industries.




Drying methods, solvents and extraction methods greatly modify the phytochemical compounds and biological activity from plant materials. The aims of the study would determine the results of different drying methods, various solvents and extraction methods around the phytochemical compounds and antioxidant capacity from Xao tam phan (Paramignya trimera) root purchased from Vietnam. The final results indicated that microwave drying was an efficient method in removing water regarding shortest drying time, lowest energy consumption and greatest retention of phytochemical compounds and antioxidant capacity from the P. trimera root while methanol and microwave-assisted extraction were the most effective solvent and way of greatest extraction in the phytochemical compounds and antioxidant capacity from your P. trimera root. The findings using this study allow retaining the greatest amounts of phytochemical compounds and antioxidant capacity from the P. trimera root for potential application within the nutraceutical industry.


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